Cepharanthine千金藤堿

CAS:481-49-2

僅用于工業(yè)應(yīng)用或科學(xué)研究，不可用于人類或動(dòng)物的臨床診斷或治療，非藥用。

Cepharanthine 是一種可以從植物 Stephania?cephalantha ?Hayata中分離出來(lái)的天然產(chǎn)物。Cepharanthine 具有抗SARS-CoV-2 的活性。Cepharanthine 對(duì)病毒增殖有良好的抑制作用 (半數(shù)最大 (50%) 抑制濃度 (IC₅₀) 和 90% 抑制濃度 (IC₉₀) 值為 1.90 和 4.46?µM。Cepharanthine 還能有效逆轉(zhuǎn) K562 細(xì)胞中 P-gp 介導(dǎo)的多重耐藥性，并增強(qiáng)異種移植小鼠模型中抗癌藥物的敏感性。Cepharanthine 對(duì)人肝細(xì)胞色素 P450 酶 CYP3A4，CYP2E1 和 CYP2C9具有抑制作用。

Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC₉₀) values of 1.90 and 4.46?µM.Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model.

Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects.